Yes, you'll lose some muscle on GLP-1s. But the right approach can minimize it — and new combination treatments are changing the game entirely.
The BELIEVE trial combined semaglutide with bimagrumab (a myostatin inhibitor) and achieved 22.1% total weight loss with 92.8% coming from fat mass — compared to just 71.8% with semaglutide alone. This represents 67% greater muscle preservation. While bimagrumab isn't available yet, this proves muscle loss isn't inevitable.
Let's be honest: rapid weight loss always involves some muscle loss. With GLP-1s alone, roughly 25-40% of weight lost is lean mass. But resistance training, adequate protein, and emerging combination therapies can significantly improve these ratios.
Research, protocols, and practical strategies for preserving muscle mass while losing fat on GLP-1 medications.
How semaglutide + bimagrumab achieved near-optimal body composition.
ProtocolEvidence-based protocol: protein targets, training frequency, and supplementation.
GuideCan you build muscle while cutting on GLP-1s? What the research says.
GuideWhy you need more protein than you think — and how to hit targets with reduced appetite.
ProtocolOptimal frequency, volume, and intensity for muscle preservation during weight loss.
ExplainerWhat's actually happening, who's at risk, and what you can do about it.
Compare GLP-1 telehealth providers and find the right fit for your goals.